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Initiation and use of PD Medication

Initiation and use of PD Medication

Initiation and use of PD medication - Variable Definition Table:

Field Name	Description	Values
on_levodopa	Is subject taking levodopa?	Yes No Unknown Null
on_dopamine_agonist	Is subject taking a dopamine agonist?	Yes No Unknown Null
on_other_pd_medications	Is subject taking some other PD medication(s)?	Yes No Unknown Null
use_of_pd_medication	Is subject on medication for PD?	Yes No Unknown Null
date_of_pd_medication_initiation	Date Of PD Medication Initiation	YYYY-MM format
pd_medication_start_date	PD medication Start Date	YYYY-MM format
date_of_pd_medication_recent_use	Date of recent PD medication use	YYYY-MM format

Tables that Reference this Variable:

PD Medical History

Data Type Information:

Field Name	Type	Mode
on_levodopa	STRING	NULLABLE
on_dopamine_agonist	STRING	NULLABLE
on_other_pd_medications	STRING	NULLABLE
use_of_pd_medication	STRING	NULLABLE
date_of_pd_medication_initiation	STRING	NULLABLE
pd_medication_start_date	STRING	NULLABLE
date_of_pd_medication_recent_use	STRING	NULLABLE

Curation Notations:

PD medication names were aligned with the provided by CDH list of relevant pd medications and pd medication class.
For PD medication start date (yyyy-mm) the earliest date from the list of pd medication names was used. Fields “CMINDC” (Indication), “DISMED” (PD Medication?), “CMTRT” (Med Name) in PPMI and BioFIND Concomitant_Medications.csv and Concomitant_Medication_Log.csv were used to extract pd medication name, clean and further align it with the list of relevant pd medications to determine STARTDT (start date).

Query Definition

PD_Medical_History.pd_medication_initiation_months_after_baseline is not null OR PD_Medical_History.use_of_pd_medication is not null

Clinical Data Forms Queried (available as a BigQuery Table and csv File)

PD_Medical_History

Criteria

pd_medication_initiation_months_after_baseline is not null

use_of_pd_medication is not null

Query

SELECT left(participant_id, 2) Cohort, count(distinct participant_id) Count from `amp-pd-research.2021_v2_5release_0510.PD_Medical_History` WHERE pd_medication_initiation_months_after_baseline is not null OR use_of_pd_medication is not null GROUP BY Cohort ORDER BY Cohort

Initiation and use of PD Medication